Overview
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28
Status:
Completed
Completed
Trial end date:
2014-09-05
2014-09-05
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this protocol is to measure peripheral benzodiazepine receptors in the brain using positron emission tomography (PET) and compare the imaging results between patients and healthy people.Phase:
Phase 1Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
National Institute of Mental Health (NIMH)
Criteria
- INCLUSION CRITERIA:Common to patients with neurocysticercosis and healthy subjects:
Ages between 18 and 75, inclusive.
Patients must meet the inclusion criteria of protocol 85-I-0127.
CONTROL SUBJECTS:
Are healthy based on history, physical exams, ECG, and lab tests.
EXCLUSION CRITERIA:
COMMON TO ALL SUBJECTS:
Current psychiatric illness, substance abuse or severe systemic disease based on history
and physical exam.
ECG with clinically significant abnormalities. Any existing physical exam and ECG within
one year will be reviewed and if none already exists in the chart, these will be obtained
and reviewed.
Prior participation in other research protocols or clinical care in the last year such that
radiation exposure would exceed the annual guideline of RSC.
Pregnancy or breast feeding.
Claustrophobia.
Positive HIV test.
Cannot lie on back for a few hours for the PET scans.
Presence of ferromagnetic metal in the body or heart pacemaker.
ADDITIONAL EXCLUSION CRITERIA FOR PATIENTS:
Medically unstable.
Seizures are not well controlled with medications.
A history of brain disease other than neurocysticercosis.
Laboratory tests with clinically significant abnormalities unrelated to neurocysticercosis
or its treatment.
ADDITIONAL EXCLUSION CRITERIA FOR HEALTHY SUBJECTS:
Laboratory tests with clinically significant abnormalities.
A history of brain disease.
The usage of nonsteroidal and other anti-inflammatory medications is not an exclusion
criterion.